About
How we find, verify and grade research
How studies are found in PubMed, verified, graded A–D, and reviewed before publication, plus the limits of animal and cell evidence.
By the KPV Peptide editorial team · Last reviewed · Editorial review: pending
Short answer
Every study on this site was found through PubMed, has its bibliographic details pulled from PubMed’s own records, is summarised as what the study measured, is graded by model type, and is reviewed by a person before it is published. Regulatory statements quote the regulator’s own document with a retrieval date.
1. Search
We query PubMed for KPV with peptide or inflammation terms, Lys-Pro-Val, α-MSH(11-13) and Lys-D-Pro-Val. The November 2026 run returned 140 records. Each is screened by title and abstract; we keep studies that tested the tripeptide, a close analogue (flagged as such), or a KPV formulation (also flagged), and narrative reviews for context. We exclude papers where “KPV” is unrelated or the tripeptide was not tested.
2. Verify
- Title, journal, year, authors and DOI come from PubMed E-utilities, never retyped.
- Each summary is checked against the abstract; where the abstract does not report a sample size, the record says so.
- Chemical identity comes from PubChem and FDA’s substance registry, with each value attributed.
- Regulatory text is read in the primary document. If a regulator’s site cannot be retrieved, the section is marked pending rather than paraphrased from news.
- An automated check re-resolves every PMID and DOI before each release.
3. Describe what was measured
Summaries make the study the subject and state what was measured in which model, for example “measured colonic myeloperoxidase in mice with DSS-induced colitis”. They do not turn findings into statements about what KPV does in people.
4. Grade
| Grade | Meaning | KPV records |
|---|---|---|
| A | randomised controlled human trial | None exist |
| B | other human clinical evidence | None exist |
| C | animal (in vivo) study | See database |
| D | cell, tissue or analytical study | See database |
| R | review (context only, not evidence) | See database |
Grades describe the kind of evidence, not its quality or direction. A grade C study can be well conducted and still say nothing about humans.
Model types
- In vitro (cells)
- Ex vivo (human tissue or blood samples, no administration)
- Animal (in vivo)
- Review article
- Analytical chemistry
5. Review before publication
Each study record, regulatory source and owner link carries a review status. The production build refuses to publish any page citing a record that has not been approved by a named reviewer. See the editorial policy.
6. Keep current
The corpus was last verified on 2026-11-11. Searches are re-run and regulatory pages re-checked at each review, and pages show their last-reviewed date.